Research Scientist, In Vivo Pharmacology
Company: Takeda Pharmaceutical
Location: Boston
Posted on: October 1, 2024
Job Description:
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with Takeda's and . I further attest that all information I submit
in my employment application is true to the best of my
knowledge.Job DescriptionResearch Scientist, In Vivo Pharmacology,
GI2About the role:At Takeda, we are a forward-looking, world-class
R&D organization that unlocks innovation and delivers
transformative therapies to patients. By focusing R&D efforts
on three therapeutic areas and other targeted investments, we push
the boundaries of what is possible in order to bring life-changing
therapies to patients worldwide.Join Takeda as an Research
Scientist, In Vivo Pharmacology. You will have experience in
inflammatory disease, fibrotic and extra-cellular matrix
pathobiology, innate and adaptive cell biology and associated in
vivo models of disease to join the Gastro-Intestinal Inflammation
Research (Drug Discovery Unit).You will possess strong technical
skills and primarily be responsible for in vivo experiments with
associated ex vivo analysis to further biological understanding and
enable a translational medicine strategy for inflammatory /
fibrotic diseases of the gastro-intestinal tract and hepato-biliary
system. You may also have the opportunity to perform for in vitro
experiments. As you grow within the team, you will also execute in
vivo models of skin, lung and joint inflammation.You will support a
broad pipeline in autoimmune and inflammatory diseases by
validating targets, assessing the efficacy of therapeutic candidate
molecules from multiple modalities (biologics, small molecules,
nucleic acids and cellular therapies).How you will contribute:
- Proper handling and care of mice and other rodents, general
dosing (multiple routes - oral, IV, IP, SC) and surgical techniques
and collection and analysis of blood and tissue samples ; work
schedule flexibility to ensure optimal dosing schedules on a
project specific need will be required on a case by case
basis.
- Understands and implements study protocols in accordance with
regulatory requirements for compliance with IACUC guidelines -
ability to write IACUC protocols for new models of disease.
- Independently design and execute in vivo experiments, analyze
data and interpret results and present data to relevant
stakeholders: Knowledge of data analysis programs such as GraphPad
PRISM, MicroSoft Excel Fit, FlowJo FACS analysis, Nanostring
transcriptome analysis and Softmax Pro and/or other equivalent
software.
- Maintenance of electronic laboratory notebooks and technical
reports to support regulatory submissions as needed.
- Developing and optimizing project specific mechanistically
relevant short term pathway activation as well as disease mouse
models of disease - subsequent analysis of PK/PD and associated
disease-related pathologies by various techniques such as flow
cytometry, histology, protein multiplex ELISAs and focused or full
transcriptome / proteome analysis.
- Troubleshooting methodological and technical issues,
interpreting experimental data and literature and communicating
results to diverse groups of individuals.
- Contributing to lab and equipment maintenance and order
supplies/reagents to help build a safe, effective and efficient
working environment.
- Collaborates and communicates effectively with team members to
coordinate complex in vivo experiments, and with other departments
to facilitate cross-functional efforts.Minimum
Requirements/Qualifications:
- PhD degree in a scientific discipline (or equivalent), or
- MS with 6+ years relevant experience, or BS with 8+ years
relevant experience
- You will have a passion for innovation and desire to lead new
scientific directions, being a standout colleague with a
collaborative spirit, excellent communication, organization, and
time management skills and confident with multitasking and managing
multiple projects simultaneously.More about us:At Takeda, we are
transforming patient care through the development of novel
specialty pharmaceuticals and best in class patient support
programs. Takeda is a patient-focused company that will inspire and
empower you to grow through life-changing work.Certified as a
Global Top Employer, Takeda offers stimulating careers, encourages
innovation, and strives for excellence in everything we do. We
foster an inclusive, collaborative workplace, in which our teams
are united by an unwavering commitment to deliver Better Health and
a Brighter Future to people around the world.Takeda Compensation
and Benefits SummaryWe understand compensation is an important
factor as you consider the next step in your career. We are
committed to equitable pay for all employees, and we strive to be
more transparent with our pay practices. -For Location:Boston,
MAU.S. Base Salary Range:$108,500.00 - $170,500.00The estimated
salary range reflects an anticipated range for this position. The
actual base salary offered may depend on a variety of factors,
including the qualifications of the individual applicant for the
position, years of relevant experience, specific and unique skills,
level of education attained, certifications or other professional
licenses held, and the location in which the applicant lives and/or
from which they will be performing the job.---The actual base
salary offered will be in accordance with state or local minimum
wage requirements for the job location. -U.S. based employees may
be eligible for short-term and/ or long-term incentives. U.S. based
employees may be eligible to participate in medical, dental, vision
insurance, a 401(k) plan and company match, short-term and
long-term disability coverage, basic life insurance, a tuition
reimbursement program, paid volunteer time off, company holidays,
and well-being benefits, among others. U.S. based employees are
also eligible to receive, per calendar year, up to 80 hours of sick
time, and new hires are eligible to accrue up to 120 hours of paid
vacation. -EEO StatementTakeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law.LocationsBoston, MAWorker
TypeEmployeeWorker Sub-TypeRegularTime TypeFull time
Keywords: Takeda Pharmaceutical, Cambridge , Research Scientist, In Vivo Pharmacology, Other , Boston, Massachusetts
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