FL109 - Cambridge, MA Principal Scientist, Protein Sciences

Company: Flagship Pioneering
Location: Cambridge
Posted on: April 1, 2025

Job Description:

Flagship Labs 109, Inc (FL109) is pioneering the use of artificial intelligence, physics and hardware to transform the way we see biology. FL109 is a privately held biotech, conceived by Flagship Pioneering, which brings the courage, long-term vision, and resources needed to realize unreasonable results. Become part of our mission-driven team and help envision the future of science.About the RoleWe are seeking a dynamic and visionary Principal Scientist of Protein Sciences to build and lead our protein sciences team from the ground up. In this pivotal role, you will manage and mentor a team of talented scientists, while remaining hands-on in the lab to drive innovation and execution. Your expertise will be critical in pioneering both the adoption of best practices and the development of novel methodologies. As a key strategic partner, you will collaborate closely with our machine learning team to incorporate cutting-edge data analytics into our research processes. Your leadership and contributions will be instrumental to the success of our company, positioning us to achieve groundbreaking advancements. If you are a proactive, strategic doer eager to make a significant impact, we invite you to join our team.Key Responsibilities

• Build best practices: Create the protein sciences group at FL109, help define strategic objectives, recruit top talent, and establish foundational processes.
• Deliver results: Perform and manage protein engineering projects, including the design, expression, purification, and characterization of proteins and biomolecules.
• Innovate: Apply advanced protein engineering methods to express, purify and characterize biomolecules, import new concepts from other fields and develop new best practices by collaborating with cross-functional teams including data sciences.
• Analyze and Interpret: Identify broad implications of findings that transcend the immediate experimental context.
• Strategically Contribute: Make substantive conceptual contributions to project activities and scientific strategies.
• Document and Disseminate: Coordinate communication and patenting of findings, serving as a major contributor to these processes.The ideal candidate will have:
  • Ph.D. in Molecular Biology, Biochemistry, Protein Engineering, or a related field with minimum of 6 years of post-graduate experience.
  • Extensive experience with protein expression (cell free, bacterial, mammalian), purification (affinity, SEC, IEX, etc.) and with biochemical and biophysical characterization (SDS-PAGE, nanoDSF, BLI/SPR, etc.)
  • Experience with purification of multi-subunit complex and membrane proteins
  • Experience collaborating with computational teams is a plus, particularly in data injection, analysis, and generation of insights from computational outputs
  • Experience using automation
  • A track record of innovationFlagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
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Keywords: Flagship Pioneering, Cambridge , FL109 - Cambridge, MA Principal Scientist, Protein Sciences, Other , Cambridge, Massachusetts